P300/CBP

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P₃₀₀/CBP is a transcriptional co-activating protein involved in G protein signalling. It consists of four subunits, two regulatory and two catalytic. Binding of cAMP to the regulatory subunits causes release of the catalytic subunits. These can then enter the nucleus to interact with transcriptional factors, thus affecting gene transcription. One example of this involves the phosphorylation of CREB, which then interacts with a CRE DNA element to enhance transcription of genes that aid gluconeogenesis. This pathway is initiated by adrenaline binding to the cell of interest.