P2Y12

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purinergic receptor P2Y, G-protein coupled, 12
Identifiers
Symbol(s) P2RY12
Entrez 64805
OMIM 600515
RefSeq NM_022788
UniProt Q9H244
PDB 1VZ1
Other data
Locus Chr. 3 q24-q25

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P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) found on the cell surface of blood platelet cells. Belongs to group of nucleotide or purinergic receptors. It is an important regulator in blood platelet coagulation. The drug Clopidogrel binds to this receptor and is marketed as a platelet anticoagulant. In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration, in which this method of platelet anticoagulant therapy was used [1].

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