Oxprenolol

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Oxprenolol
Systematic (IUPAC) name
1-propan-2-ylamino-3-(2 -prop-2-enoxyphenoxy)-propan-2-ol
Identifiers
CAS number	6452-71-7
ATC code	C07AA02
PubChem	4631
Chemical data
Formula	C15H23NO3
Mol. weight	265.348
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Hepatic
Half life	1-2hours
Excretion	Renal Lactic (In lactiferous females)
Therapeutic considerations
Pregnancy cat.	C(AU)
Legal status	℞ Prescription only
Routes	oral

Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. (McDevitt 1987)

[edit] References

• McDevitt DG. Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs. Eur Heart J. 1987 Dec;8 Suppl M:9-14. Review. PMID 2897304.

Beta blockers (C07) edit
Non-selective β antagonists (C07AA) edit Metipranolol, Nadolol, Oxprenolol, Penbutolol, Pindolol, Propranolol, Timolol, Sotalol	β1 antagonists (cardioselective) (C07AB) edit Atenolol, Acebutolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Nebivolol	Mixed α1/β antagonists (C07AG) edit Carvedilol, Labetalol