Number-one singles in Ireland (2006)
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This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2006.
| Issue Date | Song | Artist |
| January 5 | That's My Goal | Shayne Ward |
| January 12 | That's My Goal | Shayne Ward |
| January 19 | That's My Goal | Shayne Ward |
| January 26 | That's My Goal | Shayne Ward |
| February 2 | That's My Goal | Shayne Ward |
| February 9 | That's My Goal | Shayne Ward |
| February 16 | That's My Goal | Shayne Ward |
| February 23 | Jumbo Breakfast Roll | Pat Shortt |
| March 2 | Jumbo Breakfast Roll | Pat Shortt |
| March 9 | Jumbo Breakfast Roll | Pat Shortt |
| March 16 | Jumbo Breakfast Roll | Pat Shortt |
| March 23 | Jumbo Breakfast Roll | Pat Shortt |
| March 30 | Jumbo Breakfast Roll | Pat Shortt |
| April 6 | Crazy | Gnarls Barkley |
| April 13 | No Promises | Shayne Ward |
| April 20 | Crazy | Gnarls Barkley |
| April 27 | Crazy | Gnarls Barkley |
| May 4 | Crazy | Gnarls Barkley |
| May 11 | Crazy | Gnarls Barkley |
| May 18 | Crazy | Gnarls Barkley |
| May 25 | Crazy | Gnarls Barkley |
| June 1 | Crazy | Gnarls Barkley |
| June 8 | I Wish I Was a Punk Rocker (with Flowers in My Hair) | Sandi Thom |
| June 15 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| June 22 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| June 29 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| July 6 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| July 13 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| July 20 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| July 27 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| August 3 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| August 10 | Hips Don't Lie | Shakira feat. Wyclef Jean |
| August 17 | Everytime We Touch | Cascada |
| August 24 | Everytime We Touch | Cascada |
| August 31 | SexyBack | Justin Timberlake |
| September 7 | SexyBack | Justin Timberlake |
| September 14 | SexyBack | Justin Timberlake |
| September 21 | SexyBack | Justin Timberlake |
| September 28 | Everytime We Touch | Cascada |
| October 5 | Everytime We Touch | Cascada |
| October 12 | Everytime We Touch | Cascada |
| October 19 | Everytime We Touch | Cascada |
| October 26 | Irreplaceable | Beyoncé |
| November 2 | Irreplaceable | Beyoncé |
| November 9 | The Saints Are Coming | U2 & Green Day |
| November 16 | The Rose | Westlife |
| November 23 | Smack That | Akon |
| November 30 | Smack That | Akon |
| December 7 | Smack That | Akon |
