Norfloxacin
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Norfloxacin
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| Systematic (IUPAC) name | |
| 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline- 3-carboxylic acid |
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| Identifiers | |
| CAS number | 70458-96-7 |
| ATC code | J01MA06 S01AX12 |
| PubChem | 4539 |
| DrugBank | APRD00469 |
| Chemical data | |
| Formula | C16H18N3FO3 |
| Mol. weight | 319.331 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 3 to 4 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Norfloxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections.
[edit] Mechanism of action
The mechanism of action of norfloxacin involves inhibition of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication.[1]
[edit] References
- ^ Goldstein E (1987). "Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity". Am J Med 82 (6B): 3–17. PMID 3111257.
| Quinolones (J01M) edit | ||
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| Fluoroquinolones: |
Ciprofloxacin, Enoxacin, Fleroxacin, Gatifloxacin, Gemifloxacin, Grepafloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Norfloxacin, Ofloxacin, Pefloxacin, Prulifloxacin, Rufloxacin, Sparfloxacin, Temafloxacin, Trovafloxacin, Sitafloxacin |
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| Other quinolones: |
Cinoxacin, Flumequine, Nalidixic acid, Oxolinic acid, Pipemidic acid, Piromidic acid, Rosoxacin |
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