Nodal (protein)
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| Nodal | |
|---|---|
| Genetic data | |
| Gene code: | HUGO code:NODAL |
| Protein Structure/Function | |
| Protein type: | cytokine |
| Functions: | cell differentiation |
| Domains: | TGFβ domain |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | Extracellular |
| Medical/Biotechnological data | |
| Diseases: | Situs Ambiguus Mendelian Inheritance in Man (OMIM) 601265 |
Nodal is a polypeptide member of the TGF beta superfamily of polypeptides. Like many other members of this superfamily, it is involved in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation[1].
| Identifiers | |
| Symbol(s) | NODAL |
| Entrez | 4838 |
| OMIM | 601265 |
| RefSeq | NM_018055 |
| UniProt | Q96S42 |
| Other data | |
| Locus | Chr. 10 q22.1 |
[edit] References
- ^ Reissmann E,, Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH. (Aug 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15). Entrez PubMed 11485994. Retrieved on 2006-07-05.
| TGF beta signaling pathwayedit | |
|---|---|
| TGF beta superfamily of ligands: | |
| Activin A | Activin B | Anti-müllerian hormone | BMP2 | BMP3 | BMP4 | BMP5 | BMP6 | BMP7 | BMP8a | BMP8b | BMP10| BMP15 | GDF1 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDF10 | GDF11 | GDF15| Inhibin A | Inhibin B | Myostatin | Nodal | TGFβ1 | TGFβ2 | TGFβ3 | |
| Type II receptors: ACVR2A | ACVR2B | AMHR2 | BMPR2 | TGFBR2 | TGFBR3 | |
| Type I receptors: ACVR1A | ACVR1B | ACVR1C | ACVRL1 | BMPR1A | BMPR1B | TGFBR1 | |
| Signal transducers: SMAD1 | SMAD2 | SMAD3 | SMAD4 | SMAD5 | SMAD6 | SMAD7 | SMAD9 | |
| Ligand Inhibitors: Cerberus | Chordin | DAN | Decorin | Follistatin | Gremlin | Lefty | LTBP1 | Noggin | THBS1 | |
| Coreceptors: BAMBI | Cripto Other: SARA |
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