Nisoldipine
From Wikipedia, the free encyclopedia
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Nisoldipine
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| Systematic (IUPAC) name | |
| methyl2- methylpropyl2,6-dimethyl-4-(2-nitrophenyl)- 1,4-dihydropyridine-3,5-dicarboxylate | |
| Identifiers | |
| CAS number | 63675-72-9 |
| ATC code | C08CA07 |
| PubChem | 4499 |
| DrugBank | APRD00635 |
| Chemical data | |
| Formula | C20H24N2O6 |
| Mol. weight | 388.414 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 99% |
| Metabolism | ? |
| Half life | 7-12 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Nisoldipine is a calcium channel blocker of the dihydropyridine class. It sold under the proprietary name Sular.
[edit] External links
- DDB 30009
- Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167-71. PMID 15834448.
- Missan S, Zhabyeyev P, Dyachok O, Jones S, McDonald T (2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine.". Br J Pharmacol 140 (5): 863-70. PMID 14530219.
- Hamilton S, Houle L, Thadani U. "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279-88. PMID 11720635.
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| Calcium channel blockers (C08) edit | ||
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| Dihydropyridines: |
Amlodipine, Felodipine, Isradipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nimodipine, Nisoldipine |
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| Phenylalkylamines: | ||
| Benzothiazepines: | ||
