Niobocene dichloride
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| Niobocene dichloride | |
|---|---|
 |
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| General | |
| Systematic name | Dichlorobis(η5-cyclopentadienyl)- niobium(IV) |
| Other names | Niobocene dichloride |
| Molecular formula | C10H1oCl2Nb |
| Molar mass | 294 g/mol |
| Appearance | brown solid |
| CAS number | [12793-14-5] |
| Properties | |
| Density and phase | |
| Solubility in water | insoluble |
| Other solvents | sparingly in chlorocarbons |
| Melting point | |
| Boiling point | dec. |
| R/S statement | R: 36/37/38 S: 26-36 |
| RTECS | QU0400000 |
| Related compounds | Cp2TiCl2 Cp2MoCl2 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Niobocene dichloride, formally dichlorobis(η5-Cyclopentadienyl)niobium(IV), is the chemical compound with the formula (C5H5)2NbCl2 or Cp2NbCl2. This paramagnetic brown solid is a useful starting reagent. It is being investigated as an anti-cancer agent.[1]
The compound is a pseudotetrahedral with two cyclopentadienyl and two chloro substituents attached to the metal. A variety of similar compounds are known, including Cp2TiCl2.
It is prepared via a multistep reaction beginning with reductive alkylation of niobium pentachloride with cyclopentadienylsodium:[2]
- NbCl5 + 6 NaC5H5 → 5 NaCl + (C5H5)4Nb + organic products
- (C5H5)4Nb + 2 HCl + 0.5 O2) → [{C5H5)2NbCl}2O]Cl2 + 2 C5H6
- 2 HCl + [{(C5H5)2NbCl}2O]Cl2 + SnCl2 → 2 (C5H5)2NbCl2 + SnCl4 + H2O
[edit] References
- ^ Mokdsi, G.; Harding, M. M. "A 1H NMR study of the Interaction of Antitumor Metallocenes with Glutathione" Journal of Inorganic Biochemistry 2001, Volume 86, Pages 611-616.
- ^ Lucas, C. R. "Dichlorobis(η5-Cyclopentadienyl)Niobium(IV)" Inorganic Syntheses, 1990, volume 28, pages 267-270. ISBN 0-471-52619-3.
