Nilutamide

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Nilutamide chemical structure
Nilutamide
Systematic (IUPAC) name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]
imidazolidine-2,4-dione
Identifiers
CAS number 63612-50-0
ATC code L02BB02
PubChem 4493
DrugBank APRD00150
Chemical data
Formula C12H10N3F3O4 
Mol. weight 317.221 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 38.0 to 59.1 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. Nilutamide blocks the androgen receptor, preventing its interaction with testosterone. This leads to a decrease in dihydrotestosterone (DHT) production. Because most prostate cancer cells rely on DHT for growth and spread, nilutamide can prolong life in men with prostate cancer. Nilutamide is marketed under the name Nilandron in the United States.

[edit] References

  • Kassouf W, Tanguay S, Aprikian AG. Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J. Urol. 2003 May;169(5):1742-4. PMID 12686822
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Sex hormones and related medications (primarily G03, also L02, H01C) edit
Progestogens:
(receptor)

Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone
Antiprogestogen: Mifepristone
Androgens:
(receptor)

Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, Testosterone, (see also anabolic steroids)
Antiandrogens: Bicalutamide, Cyproterone, Flutamide, Nilutamide, Spironolactone
Estrogens:
(receptor)

Chlorotrianisene, Dienestrol, Diethylstilbestrol, Estradiol, Estriol, Estrone, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate
Selective estrogen receptor modulator: Bazedoxifene, Clomifene, Fulvestrant, Raloxifene, Tamoxifen, Toremifene
Aromatase inhibitor: Aminogluthetimide, Anastrozole, Exemestane, Formestane, Letrozole, Vorozole
Gonadotropins:
(FSHR/LHCGR)

ovulation stim.: Clomifene, Urofollitropin
Antigonadotropins: Danazol, Gestrinone
GnRH:
(receptor)

Gonadotropin-releasing hormone agonist: Buserelin, Goserelin, Leuprorelin, Nafarelin, Triptorelin
Gonadotropin-releasing hormone antagonist: Histrelin, Abarelix
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