Nikolsky's sign

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Nikolsky's sign is a clinical dermatological sign in which blisters spread easily upon application of tension at the base of the lesion. Positive Nikolsky's sign signifies an intraepidermal splitting of keratinocytes, as in the potentially fatal autoimmune skin disorder Pemphigus vulgaris. (Contrast from tense blisters; subepidermal blisters)

The sign is also found in Staphylococcal scalded skin syndrome and Toxic Epidermal Necrolysis.

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