Nicorandil
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Nicorandil is a drug used to treat coronary heart disease. It is marketed as Ikorel ®.
It acts by relaxing the smooth muscle of the coronary arteries and also the smooth muscle in vascular muscle. It does this through two methods. Firstly it is a potassium channel activator, and secondly it donates NO to activate guanylate cyclase. Guanylate cyclase then causes activation of GMP leading to both arterial and venous vasodilatation.
[edit] Reference
- Kukovetz WR et al (1992). Molecular mechanism of action of nicorandil. Journal of Cardiovascular Pharmacology 20 Suppl.3:S1-S7.
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