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Net Terminal Genes are a plot device in the manga Blame! by Tsutomu Nihei. They are a special gene that can be used by the lucky recipient to create a user identity for the Netsphere. However, the Net Terminal Genes are incredibly rare by the time Blame! begins. The Net Sphere protection agency, also called Safeguard, is under standing orders to kill any human found who does not possess the genes; also, any illegal access to the Netsphere is responded to by downloading a Safeguard to the location of the illegal access point and having it kill the person who tried to access. As very few humans have the net gene any more, the Safeguards are essentially under orders to kill humanity, a goal that is shared by the enigmatic Silicon Life.
