Nebulin

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nebulin
Identifiers
Symbol(s)	NEB NEM2
Entrez	4703
OMIM	161650
RefSeq	NM_004543
UniProt	P20929
Other data
Locus	Chr. 2 q22

Nebulin is an actin-binding protein which is localized to the I-band in skeletal muscle. It is a very large protein (600-900 kDa) and binds as many as 200 actin monomers. Its length is proportional to thin filament length.

The interaction of nebulin with actin is Calcium-Calmodulin sensitive.

Mutations in nebulin cause some cases of the autosomal recessive disorder nemaline myopathy.

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MeSH nebulin

Proteins of the cytoskeleton v • d • e
Microfilaments	Actins \| Myosins \| Actin-binding proteins
Intermediate filaments	IFAPs \| Keratins \| Lamins \| Neurofilaments \| Type III IF proteins
Microtubules	Dyneins \| Kinesins \| MAPs \| Tubulins
Prokaryotic cytoskeleton	Crescentin \| FtsZ \| MreB
Other	Major Sperm Proteins