Nebivolol

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Nebivolol
Systematic (IUPAC) name
1-(6-fluorochroman-2-yl)-{[2-(6-fluorochroman-2-yl)- 2-hydroxy-ethyl]amino}ethanol
Identifiers
CAS number	99200-09-6
ATC code	C07AB12
PubChem	71301
Chemical data
Formula	C22H25NF2O4
Mol. weight	405.435 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	98%
Metabolism	Hepatic (CYP2D6-mediated)
Half life	10 hours
Excretion	Renal and fecal
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM (UK)
Routes	Oral

Nebivolol is a selective beta₁ receptor blocker used in treatment of hypertension. It is marketed under the brand name Nebilet®. Nebivolol is manufactured by Forest Laboratories, Inc. In most countries, this medication is available only by prescription. Mylan Laboratories licensed the U.S. and Canadian rights to nebivolol from Janssen Pharmaceutica N.V. in 2001. Nebivolol is already registered and successfully marketed in more than 50 other countries outside of North America.

Beta blockers (C07) edit
Non-selective β antagonists (C07AA) edit Metipranolol, Nadolol, Oxprenolol, Penbutolol, Pindolol, Propranolol, Timolol, Sotalol	β1 antagonists (cardioselective) (C07AB) edit Atenolol, Acebutolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Nebivolol	Mixed α1/β antagonists (C07AG) edit Carvedilol, Labetalol