Nafcillin
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Nafcillin
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| Systematic (IUPAC) name | |
| 7-[(2-ethoxynaphthalen-1-yl) carbonylamino]- 3,3-dimethyl-6-oxo-2-thia-5-azabicyclo [ 3.2.0] heptane-4-carboxylic acid | |
| Identifiers | |
| CAS number | 985-16-0 |
| ATC code | ? |
| PubChem | 8982 |
| DrugBank | APRD01130 |
| Chemical data | |
| Formula | C21H22N2O5S |
| Mol. weight | 414.476 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 90% |
| Metabolism | <30% hepatic |
| Half life | ? |
| Excretion | Biliary and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | Oral, IM, IV |
Nafcillin sodium is a beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, particularly species of Staphylococci, that are resistant to other penicillins.
[edit] Administration
Nafcillin can be given either orally (trade name Unipen®) or by injection (Nallpen®)
[edit] Side effects
As with all penicillins, serious life-threatening allergic reactions can occur.
Milder side effects include:
- Nausea and vomiting
- Diarrhea, often due to suppression of normal gastrointestinal bacteria. Occasionally, this leads to a more serious super-infection with an organism like Clostridium difficile
- Abdominal pain
- Yeast infections (thrush) affecting the mouth and tongue or vagina
| Penicillins (J01C) edit | ||
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Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, Nafcillin, Piperacillin, Pivampicillin, Ticarcillin |
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