Talk:Muscular dystrophy
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MD is a collection of twenty or more disorders. I question some of the generalizations here, such as the "Cause" -- not sure that is universal, though I'm no expert. Mine (FSH) has a genetic "cause," though calcium buildup may result causing cell damage. Just a comment/question.
Why hasn't the disease died out yet? Do female carriers of a dystrophin mutation have some competitive advantage? AxelBoldt 13:41, 25 Jun 2004 (UTC)
Most identified causes for muscular dystrophy are mutations in the gene for the protein dystrophin. It is a huge gene so there are potentially hundreds of distinct mutations that could cause muscular dystrophy (MD). For the best characterized mutations it is recessive and consists of frameshift, early termination, exon skipping, or complete gene knockout. Some of these mutations may be easier to find a cure for than others.
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[edit] Genetic disorders never die out.
There will always be new mutations creating new copies of the defective gene. The odds of mutation in a given gene rise directly in proportion with its size. Since the gene in question is very large, it has a relatively large frequency of mutation. While some genetic disorders (such as sickle cell anemia) have selective advantages which increase their allele frequency above that expected from the basal mutation rate, this characteristic is not required for recessive lethal mutations to propagate.
[edit] history?
How did this all start? Is there any history on MD? What happened a long time ago? Any help?
[edit] Sarcoglycanopathies
I am by no means a doctor, but muscular dytropy is not to my knowledge an infectious disease. Thus, surely either this link is inappropriate or the stub it leads to is inaccurately categorised. I suspect the latter or surely visitors to this page would have noticed. If anyone can suggest more appropriate categories I'd be happy to insert them. I will also alert the robot that created these categories. The Sarcoglycanopathies page itself is sleepy, hence my note here. Ben MacDui (Talk) 10:13, 25 November 2006 (UTC)
- I'm not at all familiar with said disease, but from the description in the article, I agree it doesn't sound in any way infectious. My 'bot restubbed it on the basis of the existing category, which was altered in this earlier edit. I've removed the permcat, and changed the stub template back to {{disease-stub}}. Alai 12:12, 25 November 2006 (UTC)
Sarcoglycanopathies? no where could I find that this has anything to do with Muscular dystrophy and I agree with Alai, Muscular Dystrophy is not infectious and can only be inherited Chad19r 3:20, 26 November 2006 (UTC)
[edit] Filled in alot of Info
I have Muscular Dystrophy and took the time to add a few sections Symptoms, Diagnosis, and Prognosis, among various cleanup and hopefully you'll all feel that it is up to par with what is needed, and hopefully we can end up with a article that'll be the most informative. Chad19r 19:35, 25 November 2006 (UTC)
Material I have added is originally from different public domain documents and some original material references sited at bottom in page I found tons info around the sites and condensed as much as I could without being overdone in this article I hope it sounds good to everyone Chad19r 3:25, 26 November 2006 (UTC)
[edit] Cause section inaccurate
The cause section on this article is inaccurate. Not ALL muscular dystrophies are X-linked. Definitely Duchenne and Becker's are, but many are not (i.e. they are on other chromosomes). I am in the middle of studying for med school exams so I don't have time to edit that section right now, think somebody else can? I'll try to get to it later if I remember... Wilk 54 03:32, 12 December 2006 (UTC)
