Mucous membrane pemphigoid
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| ICD-10 | L12 |
|---|---|
| ICD-9 | 694 |
Mucous membrane pemphigoid is an autoimmune reaction that occurs at the level of the basement membrane. Commonly affects gingiva. Desquamating/blistering disease in which epithelial separation takes place at the level of the basement membrane.
Antibodies (IgG) precipitates complement (C3) in the lamina lucida of the BM. Circulating auto-antibodies to BP-1 antigen (located in hemidesmosome). 50% have BP-2. Positive Nikolsky sign. IgG, C3 deposition at BM creating smooth line in immunoflourescent analysis.
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