MSin3 interaction domain
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- The correct title of this article is mSin3 interaction domain. The initial letter is shown capitalized due to technical restrictions.
The mSin3 interaction domain (SID) is present on several transcriptional repressor proteins including TGFβ (transforming growth factor β) and Mad. It interacts with the paired amphipathic alpha-helix 2 (PAH2) domain of mSin3, a transcriptional repressor domain attached to some transcription repressor proteins such as the mSin3A corepressor.
Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.
[edit] External links
- The Smad Transcriptional Corepressor TGIF Recruits mSin3
- A 13-Amino Acid Amphipathic α-Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A
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