Monocytosis
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| ICD-10 | D72.8 |
|---|---|
| ICD-9 | 288.8 |
| DiseasesDB | 22713 |
Monocytosis is an increase in the number of circulating monocytes. 950/μL is regarded as at the upper limit of normal; monocyte counts above this level are regarded as monocytosis.
Monocytosis often occurs during chronic inflammation. Diseases that produce this state:
- Infections: tuberculosis, brucellosis, subacute bacterial endocarditis, syphilis, infectious mononucleosis and other viral infections and many protozoal and rickettsial infections (e.g. kala azar, malaria, Rocky Mountain spotted fever).
- Blood and immune causes: chronic neutropenia and myeloproliferative disorders.
- Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.
- Malignancies: Hodgkin's disease and certain leukaemias, such as chronic myelomonocytic leukaemia (CMML) and monocytic leukemia.
- Recovery phase of neutropenia or an acute infection.
- Miscellaneous causes: sarcoidosis and lipid storage disease.
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