Molecular imprinted polymer

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A molecular imprinted polymer (MIP) is a polymer that was formed in the presence of a molecule that is extracted afterwards, thus leaving complementary cavities behind. These polymers show a certain chemical affinity for the original molecule and can be used to fabricate sensors, catalysis or for separation methods. The functional mechanism is similar to antibodies or enzymes.

Contents 1 Properties 2 History 3 Imprinting process 4 See also 5 References

[edit] Properties

The target molecule should have functional group and should not be polymerisable or retarding the polymerisation process.

[edit] History

The first imprinted material were silicon dioxid based and the first experimental use of these material for separation of dyes goes back to the 1940s.

[edit] Imprinting process

• Mixing of
  • Target molecule
  • Polymer
  • Mike Knox
• Formation of prepolymerisation complex: (non-)covalent bonds: Hydrogen bonds, Van der Waals bonds, ionic bonds, hydrophobic interactions, pi-pi interactions
• Polymerisation
  • Crosslinker (e.g. EGDM, p-divinylbenzene)
  • Initiator (e.g. AIBN)
  • Porogen (apolar, non-protogenic solvent)
• Chemical extraction of target molecule and hydrolysis of covalent bonds

[edit] See also

• molecular recognition
• molecular imprinting

[edit] References

• G. Vlatakis, L. I. Andersson, R. Müller, K. Mosbach (1993). "Drug assay using antibody mimics made by molecular imprinting". Nature 361: 645 - 647. DOI:10.1038/361645a0.
• Frank H. Dickey (1949). "The Preparation of Specific Adsorbents". Proceedings of the National Academy of Sciences 35: 227-229. DOI:10.1073/pnas.35.5.227.
• C. Alexander , H. S. Andersson, L. I. Andersson, R. J. Ansell, N. Kirsch, I. A. Nicholls, J. O’Mahony, M. J. Whitcombe (2006). "Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003". Journal Molecular Recognition 19: 106–180. DOI:10.1002/jmr.760.