Missisquoi National Wildlife Refuge

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Missisquoi National Wildlife Refuge is a National Wildlife Refuge located in the eastern shore of Lake Champlain in the U.S. state of Vermont. The refuge is in Franklin County in the northwest corner of the state near the International Boundary with Canada. It is the only National Wildlife Refuge located in Vermont and is administered by the United States Fish and Wildlife Service.

The refuge was established on February 4, 1943, under the authority of the Migratory Bird Conservation Act. The initial acquisition was 1,582 acres (6.4 km²) of land in the Missisquoi River delta, including Shad Island and Big Marsh Slough. Additional land was acquired over the next 60 years. The refuge's current size is 6,642 acres (27 km²).