Mezlocillin

From Wikipedia, the free encyclopedia

Mezlocillin chemical structure
Mezlocillin
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-
2-oxo-imidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]
amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-
carboxylic acid
Identifiers
CAS number 51481-65-3
ATC code J01CA10
PubChem 656511
DrugBank APRD01113
Chemical data
Formula C21H25N5O8S2 
Mol. weight 539.584 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 16–59%
Metabolism Hepatic (20–30%)
Half life 1.3–4.4 hours
Excretion Renal (50%) and biliary
Therapeutic considerations
Pregnancy cat.

B

Legal status
Routes Intravenous, intramuscular

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria.

Contents

[edit] Mechanism of action

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

[edit] Susceptible organisms

[edit] Gram-negative

[edit] Gram-positive

[edit] External links

  • DDB 30377
  • GPnotebook -288358398
  • Duke
  • Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange.". J Neurol Neurosurg Psychiatry 64 (3): 379-81. PMID 9527154.
  • McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients.". Hepatology 25 (4): 833-6. PMID 9096584.
  • Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure.". Eur J Clin Pharmacol 53 (2): 111-5. PMID 9403281.
Penicillins (J01C) edit

Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, Nafcillin, Piperacillin, Pivampicillin, Ticarcillin