Mexiletine

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Mexiletine
Systematic (IUPAC) name
1-(2,6-dimethylphenoxy)propan-2-amine
Identifiers
CAS number	31828-71-4
ATC code	C01BB02
PubChem	4178
DrugBank	APRD00242
Chemical data
Formula	C11H17NO
Mol. weight	179.259 g/mol
Pharmacokinetic data
Bioavailability	90%
Protein binding	50-60%
Metabolism	Hepatic (CYP2D6 and 1A2- mediated)
Half life	10-12 hours
Excretion	Renal (10%)
Therapeutic considerations
Pregnancy cat.	B1(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, IV

Mexiletine (INN, sold under the trade name Mexitil®) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels.

Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002)

[edit] External links

• MedlinePlus Drug Information: Mexiletine

[edit] References

• Peck T, Hill S, Williams M (eds.) (2004). Pharmacology for Anaesthesia and Intensive Care, 2nd ed., Cambridge University Press. ISBN 0-521-68794-2.
• Sweetman S (ed.) (2002). Martindale: The complete drug reference, 33th ed., London: Pharmaceutical Press. ISBN 0-85369-499-0.

Antiarrhythmic agents (C01B)edit
class Ia:	Ajmaline, Disopyramide, Prajmaline, Procainamide, Quinidine, Sparteine
class Ib:	Aprindine, Lidocaine, Mexiletine, Tocainide
class Ic:	Encainide, Flecainide, Lorcainide, Moricizine, Propafenone
class II:	Propranolol, Metoprolol, Nadolol, Atenolol, Acebutolol, Pindolol, Sotalol see Beta blockers (C07)
class III:	Amiodarone, Bretylium tosilate, Bunaftine, Dofetilide, Ibutilide
class IV:	Verapamil, Diltiazem see Calcium channel blockers (C08)
class V:	Adenosine, Atropine, Digoxin