Talk:Methylene blue
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[edit] Colour?
From the sources I've been checking out there seems to be a conflict of information on what colour methylthionine chloride actually is. Having never handled it myself, I can't be sure. From some sources, Wikipedia included, I see 'distinct blue' colour which fades with dropping oxygen levels (makes sense given the name) but I also see consistent sources claiming it is dark green such as this one. Am I missing something obvious here? T-Dawg 14:58, 24 February 2006 (UTC)
- I've recently used methylene blue in a concentration of 2g/lt and obtained a dark blue solution. However solid methylene blue crystals are dark green. Thus I believe that the answer to your question would be: methylene blue powder/crystals are green, but they yield a blue solution when dissolved in water. Hope this helps. Berserker79 15:53, 24 February 2006 (UTC)
- I too can confirm that at a concentration of 0.001% in distilled water, a methylene blue solution appears dark blue. Also, absorption maximum for methylene blue is 601nm, incase anyone doing some spectrophotometry needs to know (I don't know if this tidbit is important enough to go in the actual article, so i'll put it here and let someone else decide). Ta! --mark
[edit] Methylene Blue
At what temperature and/or pressure will it take to oxidize methylene blue?
- It's not a question of temperature or pressure - it depends on the chemical (redox) environment. An oxidant (like oxygen, or potassium permanganate) will oxidize it and turn it blue. A reductant (like 2-mercaptoethanol) will reduce it and turn it colorless. Why the question? Ignoramibus 05:24, 16 August 2006 (UTC)
[edit] Pranks?
Why is there a prank listed in the article under uses? Firstly, it's topical, generally pointless/useless, and completely uncited content. Secondly, it's somewhat unsettling given the warning note under the medicine uses category. Not to mention that Methylene Blue is a WHMIS class D division 2 compound, and shouldn't be used as a prank on anyone at any volume regardless of it's purification. Whoever added this appears to condone potentially hazardous acts -- plz keep this sort of thing to your blog. Imho, it's really just disrespectful and stupid... even for Biochemist standards :P --mark
- Well, I've got to agree with you about that "Pranks" section. I never went ahead to remove it because I thought it was just me who thought that stuff sounded stupid/dangerous (I tend to be a little overcautious with anything chemical...). As soon as I find some time I'll check that paragraph again and see if there's anything useful to save, then remove it. BTW, that info you mentioned about the methylene blue absorption sounds useful, you should add it to the article. Berserker79 07:02, 20 September 2006 (UTC)
Concerning this 'WARNING Methylene Blue is known to increase CNS leves ...'. I would like to know the references this is based on, because I have recently published about this and want to know if the Au of those comments has refs I am unaware of. It may well be a prescient warning. I shall be publishing more about this soon.Ken Gillman 23:36, 20 September 2006 (UTC)
I think it is important to have a paragraph about the prank, because if I hadn't read this just now and had blue urine one day, the first thing I would do is look it up on Wikipedia. Seriously. subasd 17:19, 9 October 2006 (UTC)
Nothing wrong with a pranks sections but that is is comparable in length to the treatment section perhaps shows some problem with priorities or sense of proportion. --Gak 21:08, 15 October 2006 (UTC)
I vote to keep the pranks sections. The mere description of a behavior on Wikipedia is in no sense an endorsement of that activity. And the fact is, dosing unsuspecting colleagues with methylene blue (at relatively innocuous levels) has a long and dubious history among chemists and biochemists. Ignoramibus 03:34, 27 October 2006 (UTC)
[edit] Warning
This warning may actually be quite prescient, but without any indication of the sources it is based on is of limited use or assistance. It is probably something of an over generalisation, and somewhat imprecise. The only circumstance in which methylene blue is likely to be dangerous in patients is when it is infused intravenously in large doses. As far as I am aware this is only done for the purpose of highlighting the parathyroid tissues during thyroidectomy, in order to avoid damaging them. The doses used are in the region of five to 10 milligrams per kilogram body weight, infused just before and during surgery. At such doses it appears Clear that it has various relevant pharmacological effects in humans, although from my research these appear incompletely documented and partially understood. It would appear to be a significant monoamine oxidase inhibitor, and that means it maybe capable of producing serious, and even fatal, serotonin toxicity if combined with any drug that has significant potency as a serotonin reuptake inhibitor. My publication referred to above [1] has references relevant to this, and further material is, and/or will be very soon, available on my website. Assistants in understanding the chemistry of this from those with appropriate knowledge would be most useful because patients may die as a result of imperfect understanding and knowledge concerning this. It may be of interest for others to know that in the brief interval of two weeks since my publication came on line, and since I added a note here, I have received two reports of SerotoninToxicity involving methylene blue. It is beginning to look as though it is significant issue that has hitherto been unrecognised. Wiki people can make a real contribution to patient care and safety, please communicate your information, and try to give original references wherever possible.Ken Gillman 00:40, 27 September 2006 (UTC)
[edit] This article mentioned
I know this is not a big deal, but this article was used as a source for a cre.ations.net article on how to make you urine blue. Delta Tango • Talk 23:54, 27 November 2006 (UTC)
