Metirosine
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Metirosine
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| Systematic (IUPAC) name | |
| 2-amino-3-(4-hydroxyphenyl)-2-methyl-propanoic acid | |
| Identifiers | |
| CAS number | 672-87-7 |
| ATC code | C02KB01 |
| PubChem | 10123 |
| Chemical data | |
| Formula | C10H13N1O3 |
| Mol. weight | 195.215 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 3.4 - 3.7 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
[edit] Mechanism of action
Metirosine is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis.
[edit] Clinical Use
Metirosine is used in the treatment of phaeochromocytoma. It is contra-indicated for the treatment of essential hypertension.
| Antihypertensives (C02) and diuretics (C03) edit | ||
|---|---|---|
| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
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