Methoxyflurane
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Methoxyflurane
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| Systematic (IUPAC) name | |
| 2,2-dichloro-1,1-difluoro-1-methoxy-ethane | |
| Identifiers | |
| CAS number | 76-38-0 |
| ATC code | N01AB03 |
| PubChem | 4116 |
| DrugBank | APRD00744 |
| Chemical data | |
| Formula | C3H4Cl2F2O |
| Mol. weight | 164.965 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Methoxyflurane (C3H4Cl2F2O) is an inhalation anesthetic used in the 1960s, but withdrawn because of detrimental effects on the kidneys. This was due to fluoride ions being produced by its metabolism in the kidney. Its minimum alveolar concentration (MAC) is 0.2, hence it is extremely potent. It has a high lipid solubility (oil:gas coefficient around 950)
Methoxyflurane is used extensively in Australian ambulance services as an emergency analgesic.
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| General anesthetics (N01A) edit | ||
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| Ethers: |
Diethyl ether, Vinyl ether, Desflurane, Enflurane, Isoflurane, Methoxyflurane, Sevoflurane |
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| Haloalkanes: | ||
| Barbiturates: |
Hexobarbital, Methohexital, Narcobarbital, Thiopental |
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| Opioids: |
Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil |
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| Others: |
Alfaxalone, Minaxolone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Nitrous oxide, Propanidid, Propofol, Xenon |
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