Metaproterenol
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Metaproterenol
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| Systematic (IUPAC) name | |
| 5-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | 9353 Compound: 4086 Substance: 9353 Compound: 4086 |
| Chemical data | |
| Formula | C11H17NO3 |
| Mol. weight | 211.258 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | inhalation / tablets |
Metaproterenol is used as a bronchodialator in the treatment of asthma. Metaproterenol is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as Metaproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
[edit] Brand Names
Alotec, Alupent, Metaprel, Metaproterenol Polistirex, Metaproterenol Sulfate Novasmasol, Orciprenaline, Orciprenalina [Inn-Spanish], Orciprenalinum [Inn-Latin], Prometa
