From Wikipedia, the free encyclopedia
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Mestranol
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| Systematic (IUPAC) name |
(8S,9S,13S,14S,17S)-17-ethynyl-3-methoxy-
13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-
cyclopenta[a]phenanthren-17-ol |
| Identifiers |
| CAS number |
72-33-3 |
| ATC code |
? |
| PubChem |
6291 |
| Chemical data |
| Formula |
C21H26O2 |
| Mol. weight |
310.43 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
? |
| Half life |
? |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
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| Routes |
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Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 µg of mestranol is pharmacokinetically bioequivalent to 35 µg of ethinylestradiol).[1]
[edit] Reference
- ^ Faigle, Johann W.; Schenkel, Lotte (1998). “Pharmacokinetics of estrogens and progestogens”, in Fraser, Ian S. (ed.): Estrogens and Progestogens in Clinical Practice. London: Churchill Livingstone, pp. 273-294. ISBN 0-443-04706-5.
| Sex hormones and related medications (primarily G03, also L02, H01C) edit |
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Progestogens:
(receptor) |
Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone
Antiprogestogen: Mifepristone
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Androgens:
(receptor) |
Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, Testosterone, (see also anabolic steroids)
Antiandrogens: Bicalutamide, Cyproterone, Flutamide, Nilutamide, Spironolactone
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Estrogens:
(receptor) |
Chlorotrianisene, Dienestrol, Diethylstilbestrol, Estradiol, Estriol, Estrone, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate
Selective estrogen receptor modulator: Bazedoxifene, Clomifene, Fulvestrant, Raloxifene, Tamoxifen, Toremifene
Aromatase inhibitor: Aminogluthetimide, Anastrozole, Exemestane, Formestane, Letrozole, Vorozole
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Gonadotropins:
(FSHR/LHCGR) |
ovulation stim.: Clomifene, Urofollitropin
Antigonadotropins: Danazol, Gestrinone
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GnRH:
(receptor) |
Gonadotropin-releasing hormone agonist: Buserelin, Goserelin, Leuprorelin, Nafarelin, Triptorelin
Gonadotropin-releasing hormone antagonist: Histrelin, Abarelix
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