Mescaline

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Mescaline
Chemical name	3,4,5-Trimethoxy- phenethylamine or 2-(3,4,5-trimethoxyphenyl) ethanamine
Chemical formula	C11H17NO3
Molecular mass	211.26 g/mol
Melting point	128–129 °C
CAS numbers	54-04-6
SMILES	NCCC1=CC(OC)=C(OC)C(OC)=C1

Mescaline (3,4,5-trimethoxyphenethylamine) is a hallucinogenic alkaloid of the phenethylamine class.

It occurs naturally in the peyote cactus (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi) and the Peruvian Torch cactus (Echinopsis peruviana), and it is also found in a number of other members of the Cactaceae. It can be extracted from these sources. Mescaline was first isolated and identified in 1897 by the German Arthur Heffter and first synthesized in 1919 by Ernst Späth.

Contents 1 Usage and history 1.1 Dosage and effects 2 Legal status 3 Chemistry 4 Effects and side effects 5 See also 6 External links 7 Categorization

[edit] Usage and history

The use of extract from peyote in Native American religious ceremonies has been noted since the earliest European contact, notably by the Huichols in Mexico.

[edit] Dosage and effects

For the drug to take effect, disk-shaped buttons are cut from the roots, on the top of the cactus, and dried. It is chewed to produce its effect or soaked in water for an intoxicating drink. The effective human dosage is 0.3–0.5 grams, with the effects lasting for up to 12 hours. Users typically experience visual hallucinations and radically altered states of consciousness, often experienced as pleasurable and illuminating but occasionally as accompanied by feelings of anxiety or revulsion. It is not physically addictive.

[edit] Legal status

In the US it was made illegal in 1970 by the Comprehensive Drug Abuse Prevention and Control Act. It was prohibited internationally by the 1971 Convention on Psychotropic Substances[1] and is categorized as a Schedule I hallucinogen by the CSA.

[edit] Chemistry

A common synthetical approach starts from 3,4,5-trimethoxybenzaldehyde. the chemecial make-up is C11H17NO3(PiHKAL entry).

[edit] Effects and side effects

One or more of the following effects may or may not accompany any individual experience with mescaline.

• Open eye visuals
• Closed-eye visuals
• New thought processes
• Dream-like scenarios
• Euphoria
• Mystical experience
• Pupil dilation
• Sensations of warm and cold
• Temporary splitting/destruction of ego
• Dizziness
• Vomiting
• Tachycardia
• Diarrhea
• Headaches
• Anxiety
• Feeling of dying
• Fear of not being able to return to normal consciousness
• Hallucinogen persisting perception disorder (HPPD)
• Irrationality of the thought-process

[edit] See also

• The Doors of Perception
• The Teachings of Don Juan
• List of notable people who have taken psychedelic drugs
• MKULTRA
• Phenethylamines
• Psilocybin
• Psychedelics in popular culture
• Peyote
• Native American Church
• PiHKAL
• Psychedelic drug
• Psychoactive drug

[edit] External links

Wikimedia Commons has media related to: Mescaline

• Mescaline at Erowid
• PiHKAL entry
• Mescaline: The Chemistry and Pharmacology of its Analogs Essay by Alexander Shulgin
• Links to external chemical sources.

[edit] Categorization

Hallucinogenic phenethylamines edit
2C-B, 2C-B-FLY, 2C-C, 2C-D, 2C-E, 2C-G, 2C-I, 2C-N, 2C-O, 2C-O-4, 2C-P, 2C-T, 2C-T-2, 2C-T-4, 2C-T-7, 2C-T-8, 2C-T-9, 2C-T-21, 2C-TFM, 3C-E, 3C-P, Br-DFLY, DESOXY, DMMDA-2, DOB, DOC, DOET, DOI, DOM, DON, Escaline, Isoproscaline, Lophophine, MDA, MMDA, Macromerine, Mescaline, Proscaline, TMA