Meleda Disease

From Wikipedia, the free encyclopedia

Meleda disease is an extremely rare, inherited skin disorder in which dry, thick patches of skin develop on the soles of the hands and feet, a condition known as palmoplantar hyperkeratosis.

It is most common on the Dalmatian island of Meleda, thought to be because of a founder affect. It is of autosomal recessive inheritance. It may be caused by a mutation on the SLURP1 gene at chromosome 8qter.