McNemar's test

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In statistics, McNemar's test is a non-parametric method used on nominal data to determine whether the row and column marginal frequencies are equal. It is named after Q. McNemar, who introduced it in 1947. It is applied to 2 × 2 contingency tables with a dichotomous trait with matched pairs of subjects.

In the following example, a researcher attempts to determine if drug has an effect on a particular disease. Counts of individuals are given in the table, with the diagnosis (disease: +/−) before treatment given in the columns (before), and the diagnosis after treatment in the rows (+/−) (after). The test requires the same subjects to be included in the before- and after measurements (matched pairs).

		before
		+	−	total
after	+	101	59	160
	−	121	33	154
	totals	222	92	314

Cells represented in the following manner by the letters a, b, c and d, The totals across rows and columns marginal totals, and the grand total is represented by n:

		before
		+	−	total
after	+	a	b	a + b
	−	c	d	c + d
	totals	a+c	b+d	n

Marginal homogeneity occurs when the row totals are equal to the column totals, a and d in each equation can be cancelled; leaving b equal to c:

In this example, "marginal homogeneity" would mean there was no effect of the treatment.

The McNemar statistic is shown below:

χ² is a chi-squared statistic with 1 degree of freedom. The formula may be re-written to correct for discontinuity:

χ² = ( | b − c | − 1)² / (b + c)

The marginal frequencies are not homogeneous, if the χ² result is significant p < 0.05. If b and/or c are small (b + c < 10) then χ² is not approximated by the chi-square distribution instead a Sign Test should be used.

An interesting observation when interpreting McNemar's test is that the elements of tha main diagonal contribute no information whatsoever to the decision if (in the above example) pre- or post-treatment condition is more favourable.