User:McDogm/LoadOne

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[edit] Load One

Fixed the information on lymphatic system

Note the lymph does not carry all digested nutrients, only fats. Alex.tan 17:07, 11 May 2005 (UTC)

See lymph, discussion section. I am not sure it is scientifically possible for GI lymph not to have protein, vitamins and minerals in it. It is kind of interesting to imagine a gigantic filter, designed by mother nature, antigen by antigen, that would keep all the gastrointestinal tract nutrients out of the lymph system. What kind of antigens would they be? How would they work? Would this system ever break down? What would happen if it did? And there would have to be a sort of direct line from the blood of the small intestine area to the portal vein, a vein or artery that would take everything directly from the GI to the liver for processing. Is it easier for disaccharides and glucose to pass through the walls of capillaries or is it easier for the molecules to enter the lymphatics? The small intestine (and large intestine) are richly lymphaticized. How the heck would that work? Why do we have a lymphatic system, anyway? Why doesn't the body just use extant capillaries to do the work of the lymph system? Is there a birth defect that involves the absence of lymphatics? That sounds scary. I think that the groin, the back and sides of the neck, the axillary area and the small intestines have the greatest number of lymph nodes. Is this GI agglomeration a vestige? An systematic appendix, as it were? It really boils down to the fact that it would be ridicuous for the body to work to exclude harmless and minerals and saccharides from its highly evloved lymph system. Also it down to some medical textbook I read in the Loma Linda University Medical Library, during winter of 1989-1990, while I was waiting for my friend to finish her Physical Therapy studying. I was also introduced to peer review helminthology at LL Medical Library. Please see my Mycetoma article, my SEA (Soluble Egg Antigen) article and the schistosomiasis article. Also, please see Mycetoma Research Center , Eumycetoma and Actinomycetoma. I also wrote miracidium. As usual, controversy is the perfect breeding ground for pleasing science fiction. But what is the word 质 doing in my ISBN 9576123577 definition for lymphatic? Are the Dutch onto something? Alternatively, is there a market for Lymph Boosters, sort of like a replacement product for the past-its-prime energy drink market, in Asia? Like, 'Your lymph is full of fat! Add iron and potassium! Your weak lymph system lacks excluded vitamins! Don't be left out! Try Pocari Sweat Lymph Enhancer! Dutch Guilder Brand!' The energy drink market is actually a management issue at this point. There are always reports of mothers feeding them to their infants, to give them 'power', and there is so much sugar in the drinks that baby teeth caries usually develops. One then waits until one's adult teeth grow in, at age 13. They are a pleasing mixture of sugar, menthol and caffeine. Dutch Lymph has a new ring to it. I am not sure it would be an energy drink, maybe it could be a tryptophan-containing product. How about ' Dutch Pocari Gold ', with a femtoscopic amount of Au in it? Dutch Pocari Zinc and Dutch Pocari Potassium and Iron would cost a lot less, but if you have to rest before a big presentation there would be little probability of not using 'DPG'. Following the old characters the Iron-Potassium Lymph Booster could be called ' Pocari Double-Axe K/Fe Dutch Regular. ' This all reminds me of that 1980s tv campaign for zinc, wherein it was said that zinc was 'more imporant than Gold for good health.' I really miss those ads. I am not sure if this is science fiction or some marketing pitch at this point. What else does the body need? How about mannose? 'Mannose Lymph Drink by Pocari Sweat' , for Buddhists would sell, I bet. Anime fans would pay for Lymph Boosters containing galactose and some non-toxic form of XeF, like 'Don't Be Weak In Space! You lack Xenon!' . Well, this is getting tiring. I hope I've made my point: There is always money in science. --McDogm 18:49, 12 May 2005 (UTC)

   Read reply on Talk:Lymphatic system. There are specific transport transmembrane proteins for the rest of the nutrients to transport them to the portal system. The lymph serves to suck up stuff elsewhere in the body, not in the digestive tract where they must be preprocessed by the liver. This is quite established physiology, AFAIK. Alex.tan 01:25, 15 May 2005 (UTC)

   At this point I can certainly say that Lymphatics are a bit non-intuitive for the lay person, as a major consituent of the public at large. In the case of energy drinks, I am sure that they are used heavily for hangover relief. How extensive is the lymphatic system involved in sucking up beer consumption by-products within the human body? Or even in the gut? Perhaps if the proposed lymphatic-targeted energy drinks were tweaked to include the presumption of post-alcoholic morning-after use they would make more sense. As long as one stresses that beer, which has no real nutritive value, is dealt with by the lymph system as it degenerates, and that food is mainly taken up by the circulatory portal system, then it makes sense. How about Your Weak Dutch Constitution Suffers From Mild Alcohol Poisoning! Don't Lose Your Job Due To Dehydration! You Need to Drink Tonight! Sapporo Beer! It would be a bit more organized in its thought if the energy drink presentation referred to the beer factor in the copy. Your Lymph System Is Cleaning Up After You! Give It A Hand! Use Dutch Factor Lymph Power Drink! Don't Let Sangha Beer Send You To The Monastery! I am sure that last one is an old joke. For some products the idiocy of the ad campaign does not exist in inverse proportion to sales figures. I suppose this could go even further with the addition of the portal system to the copy. Don't Let Your Weak Lymph System Get The Goods On Your Portal System! The Beer Council Needs You To Drink Tonight! I think I am treading the edge here of even the most gifted Asian advertising campaign, but there is still money in this.

質 [zhi4] /hostage/substance/nature/quality/--McDogm 12:31, 14 May 2005 (UTC)

淋 to describe in detail. This is the transliteration of the lim in lymph. Don't Forget Yesterday's Meeting!! Take Dutch Clock Lymph Energy Drink before you shower!! I am starting to get tired of this ad campaign.--McDogm 05:07, 19 May 2005 (UTC) [edit]

[edit] Blood Vessel Supply Within Tumors-- From Cancer

Something that isn't perfectly apparent to me is why the body supplies tumors with a full supply of blood vessels, for keeping the tumor alive, as it were. One can easily understand how a mutation can cause a single group of cells to reproduce in an unhealthy manner, but what is it that causes the body to grow a complete circulatory system for the tumor? And, along these lines, does the body also supply the tumor with nerves? And lymphatics?--McDogm 15:52, 6 May 2005 (UTC)

      A tumour requests the new blood vessels using the same methods as any non-cancerous bodily tissue. A protein called vascular endothelial growth factor VEGF is secreted by most cells which are not being supplied with enough oxygen. there is a clever and not-fully-understood control mechanism involving mRNA stability and a gene called HIF-1 that stimulates VEGF gene transcription. VEGF stimulates the growth of nearby blood vessels into the tissue.

      This process is known as angiogenesis and there is some useful information on the relevant page. A fast growing tumour is going to use up a lot of oxygen, so VEGF would be secreted anyway. However, in cancers, the genes coding for chemicals such as VEGF are permanently switched on, as these mutants are favoured by the "clonal selection" process described in the cancer article. Thus, very large amounts of these angiogenins are produced, and blood vessels form. Of course the body wouldn't "want" to supply cancers, but it cannot distinguish the tumour from a healthy tissue short on O2. Angiogenesis is a critical process in the generation of malignancy. Without it, fast growth is not possible and critically, metastasis will not occur. For these reasons, it is a key target of anti-cancer research.

      Nerve cells are very reluctant to grow in adults (unfortunately for spinal injury victims) and their growth would not be beneficial to the tumour cells, so would not be selected for. Lymph, again, is not very important to the tumour, as it is there to deal with the osmotic physiology of the entire organism and its lack would not prevent growth. See teratoma for some tumours in which strange cell differenciation (including nerve cell and presumably lymph tissue) occurs, although for completely different reasons. I hope this has answered your question. If not, explain your concerns and I'll try and work it through with you. I'll also put some of this onto the angiogenesis page. --Mike C | talk 22:11, 6 May 2005 (UTC)

Thanks; I have a sneaking amateurish suspicion that lymphatics and their development may be some kind of an adjunct of angiogenesis but since we are talking about tumors here that might not make sense from a canonical mRNA science standpoint. I'm just a solid amateur but I like lymphatics and I am sure I remember that lymphatics are essential for capillary function. A tumor without lymphatics would be undrainable as a mass of tissue. I knew that nerve doesn't really grow very much in the body after a very early stage. In terms of bedside manner and DRG days it seems to me that for the cancer patient it would be good for the doctor to be able to say something helpful about oncoangiogenesis to the patient and their family. Is that word good? Personally I think the oncoangiogenesis, as it were, is a very vulnerable part of the tumor in terms of effecting cures. It makes a lot sense to me that it is a critical topic of study. On a mundane basis oncoangiogenesis goes culturally to the paradigm of economics, in which resources are allocated quite carefullly. It really makes sense to the patient, in other words, to gain leverage over the disease through understanding the negative cultural aspects of oncoangiogenesis as compared to ordinary personal relations and current events. In other words, there is usually a quid pro quo for services rendered, or in even more colloquial terms, one has to pay the (utility) bills. That's just common sense and it is really easy to explain in lamen's terms.

The mRNA mechanisms et al are of course the core of continuing study of the cancer problem.--McDogm 15:49, 7 May 2005 (UTC)--McDogm 19:44, 7 May 2005 (UTC)

  Oncoangiogenesis is not a very current term. There is also very little point in discussing it with cancer patients - all treatments in this respect are experimental (although it is one of the underpinnings of radiation therapy). I must say that the role of lymphatic drainage is not crucial to tumorigenesis, as lymphatics usually bear a close relation to the arterial supply of any tissue and probably form together with the blood vessels.
  Tumors have no nerve supply apart from the autonomous nervous system branches that come with the blood vessels. JFW | T@lk 22:26, 7 May 2005 (UTC)

What are the genetics of tumorangiogenesis and tumorlymphiogenesis? As I understand the reading, tumors cannot grow more than 3 cubic millimeters w/o angiogenesis. What exactly does angiogenesis have to do with whether a tumor is malignant or benign, at the nuts and bolts level?--McDogm 16:20, 13 May 2005 (UTC)

Is the commencement of angiogenesis the moment of change from benign to malignant? Of course, if there is no angiogenesis, the tumor will not generally grow bigger than 3 cubic millimeters, so angiogenesis is important. But is it the central factor in malignancy? Is angiogenesis the door to curing cancer?--McDogm 13:46, 14 May 2005 (UTC)

I'm pretty sure that 'Angie' by the Rolling Stones and Genesis featuring Peter Gabriel and Phil Collins are pretty important for maintaining good health. That is indisputable. But how can this knowlege be applied to the medical community? Sometimes common knowlege is in short supply on the 'stud farm.' The thing about taking a chilled out attitude towards cancer is that the DRG Days go down. The DRG is the diagnosis code that tells the hospital how many days you get billed for through your insurance. If you have an obstruction, it comes up 'DRG 9003', for example. The hospital puts DRG 9003 into the computer and it comes up 5 days. You get billed for 5 days. If you are there for 9 days, God forbid, the hospital gets 5 days of money. If you are out in 3, the hospital gets 5 days of money. So the hospital stands to make loads of $$$ if DRG drops, and people get to spend half the time in the hospital that they were going to spend, if they weren't as healthy as they thought they were. It's important. Sometimes bedside manner is a problem as people who get a lot of comfort from being in the primary care facility need to stay there, medically, so doctors have a tough time moving people along. Medical necessity is a strong Hippocratic parameter; if someone is thriving while sucking up DRG Days it is a problem for the money. Lying in distorts the DRG Days numbers, while at the same time curing people. Which gets back to Angie and Genesis. No amount of mRNA research can replace Classic Hits 70s radio. Not to mention today's Queens of the Stone Age and Velvet Revolver. Who is Kanye West?--McDogm 13:46, 14 May 2005 (UTC) [edit]

[edit] japanese film/kanji template

hi. 'words as screen image template' not sure what you mean by "template?" do mean the inclusion of kanji within the mis-en-scene, or do you mean a mis-en-scene without kanji that's composed to resemble kanji? Nateji77 05:35, 16 May 2005 (UTC)

or a sun that looks like 日 or a kebab that looks like 串? :) i've never heard of it, but ive never made a formal study of japanese film; just watched lots of pirate japanese movies i bought in china. you might need to cite a source if other people are the same, and we'd definitely need some screen shots to juxtapose to images of the relevant kanji.

personally i see a more pressing need for things like a Benshi page, expansion of Tendency film and Pinku eiga, or a treatment of the influence of Japanese theatre (long takes, long shots, over acting) and painting (minimalist composition, compositions that violate western rules by having too much space at the top or the side) etc. treatment of genre and style on the main page (otherwise it should be called "history of japanese cinema"), which i can start on now.

Nateji77 12:37, 17 May 2005 (UTC)

okay. i get what youre saying. some of the examples i buy, some are just cigars, some are backwards (the gate in rashomon doest look like kai, 开 is drawn to look like a gate (the SC more like a torii maybe). if you do an article on it youll still need screenshots, tho, not just descriptions.

ive never heard about this, or read about (and have read stuff on japanese film by critics fluent in japanese). if there's no name for it, some quotes from directors or DPs would help.

what's the japanese word for the technique? just use that in italicized romaji. Nateji77 16:29, 19 May 2005 (UTC)

oh yeah, youre talking about yellow earth, not red sorghum; zhang yimou was dp on that, chen kaige directed. Nateji77 16:30, 19 May 2005 (UTC)

if none of us know what the japanese term is, and none of us have come across a director or a dp saying "we wanted this shot to look like this kanji, as a visual pun," then i'd say better to wait until either one of us comes across them, or someone who knows them comes across wikipedia. if we cant cite it, then it gets branded "original research," which is something wikipedia shies away from. Nateji77 12:58, 20 May 2005 (UTC)

original research (eg if someone does a correlation study on coffee drinking and heart disease) something we don't post on wikipedia, even if it's true. however, once the researhers publish it in, say a medical journal, a wikipedian can read it and include it in the article, because it's now secondary research.

it doesnt matter if it's true, if you cant cite some outside source. if this is something you and your colleagues have noticed, but no one has published on (that we know of), no director has commented on in an interview (i didnt come across any mentions in the collection of translated zhang yimou interviews) then you need to discuss "visual cjk puns in mis-en-scene" of this sort in a primary-research-appropriate venue, and then we can cite that in wikipedia. if there's a source you know in chinese or japanese, i can bust out the dictionaries and look it over, and we can use the chinese/japanese name for it in romaji, ne.

Nateji77 04:28, 21 May 2005 (UTC)