Talk:Matrix-assisted laser desorption/ionization
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[edit] Trying to Keep NPOV in History of MALDI Section
201.147.87.66 made several edits in Matrix-assisted_laser_desorption/ionization#History section effectively arguing that the “ultra fine metal plus liquid matrix method” of Tanaka is not MALDI. This is debatable, so the change of with the proper combination of laser wavelength and matrix, MALDI can be used to ionize proteins to with the proper combination of laser wavelength and matrix, a protein can be ionized is consistent with NPOV.
The statement that the Tanaka and Karas/Hillenkamp demonstration of protein ionization occurred at the same time is incorrect. Note that Karas, M. and Hillenkamp, F. Laser desorption ionisation of proteins with molecular masses exceeding 10.000 daltons. Anal. Chem. 60 (1988) 2299-2301 cites Tanaka, K., Ido, Y., Akita, S., Yoshida, Y. and Yoshida, T. Proc. Second Japan-China Joint Symposium on Mass Spectrometry. Editors Matsuda, H. and Xiao-tian, L. (Osaka, Japan, 15-18 September 1987) p. 185-188 and the latter publication was an important consideration for the Nobel committee.[1]
The argument about who deserved the 2002 Nobel Prize for soft desorption of ions is confused by the facts that Karas and Hillenkamp discovered and named MALDI yet Koichi Tanaka broke the 10 kDa barrier of laser desorption ionization of proteins. Good arguments can be made as to the relative importance of these contributions, but these arguments must be supported by facts.
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- --Kmurray 16:32, 4 May 2006 (UTC)
[edit] Good Review
- Dreisewerd K., The Desorption Process in MALDI. Chem. Rev. 2003, 103, 395-425. DOI
From the Hillenkamp group gifing a good insight in development and history of MALDI! --Stone 09:43, 23 June 2006 (UTC)
