MARCKS protein
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MARCKS proteins (myristoylated alanine-rich C-kinase substrate) play important roles in cell shape, cell motility, secretion, transmembrane transport, and regulation of the cell cycle.
They are acidic proteins with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.
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