Lofexidine
From Wikipedia, the free encyclopedia
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Lofexidine
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| Systematic (IUPAC) name | |
| 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole | |
| Identifiers | |
| CAS number | ? |
| ATC code | N07BC04 |
| PubChem | ? |
| Chemical data | |
| Formula | C11H12N2Cl2O |
| Mol. weight | 259.131 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >90% |
| Protein binding | 80–90% |
| Metabolism | Hepatic glucuronidation |
| Half life | 11 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
POM(UK) |
| Routes | Oral |
Lofexidine is an alpha2-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.
| Antihypertensives (C02) and diuretics (C03) edit | ||
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| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
