Lisuride
From Wikipedia, the free encyclopedia
| Image:Lisurid.PNG | |
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Lisuride
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| Systematic (IUPAC) name | |
| N-(6methyl-8-isoergolenyl)-N',N'-diethylurea | |
| Identifiers | |
| CAS number | 18016-80-3 |
| ATC code | G02CB02 N02CA07 |
| PubChem | 28864 |
| DrugBank | APRD00636 |
| Chemical data | |
| Formula | C20H26N4O |
| Mol. weight | 338.447 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 10-20% for lisuride hydrogenmaleate |
| Protein binding | about 15% |
| Metabolism | Hepatic |
| Half life | 2 hours |
| Excretion | renal and biliary in equal amounts |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Prescription only |
| Routes | Oral, subcutaneous, transdermal |
Lisuride (brand name in Germany Dopergin) is an antiparkinson drug of the iso-ergoline class, chemically related to the dopaminergic ergoline parkinson drugs. Lisuride is described as free base (see table on the right) and as hydrogenmaleate salt.
Contents |
[edit] History
Synthesis of Lisuride was first described in 1960.
[edit] Mode of action
Lisuride is a dopamine agonist.
[edit] Indications
[edit] See also
| Ergolines edit | ||
|---|---|---|
| Lysergic acid derivatives | ||
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Bromocriptine, Cabergoline, Ergine, Ergonovine, Ergotamine, Lysergic acid, Lysergol, d-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide |
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| Hallucinogenic lysergamides | ||
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AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD |
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| Other ergolines | ||
| Natural sources | ||
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Argyreia nervosa, Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa |
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