List of drugs affected by grapefruit

From Wikipedia, the free encyclopedia

It has been suggested that Grapefruit juice be merged into this article or section. (Discuss)

This page has a list of drugs that are known to be affected by grapefruit. These interactions are generally caused by the fruit's naringin, bergamottin, and dihydroxybergamottin interfering with the enzyme cytochrome P450 isoform CYP3A4 in the intestine. However, bioactive compounds in grapefuit juice may also interefer with p-glycoprotein and organic anion transporting polypeptides (OATPs) either increasing or decreasing bioavailability of a number of drugs.

The list is ordered by its most common chemical name, followed by alternate chemical names and various trade names.

This is an incomplete list and should not be used to verify whether a drug is safe

[edit] Interacting

The following drugs definitely interact with CYP3A4:

Bupropion, amfebutamone, Wellbutrin - rxlist.com
Paroxetine, paroxetine hydrochloride, Paxil, Seroxat, Aropax, Pondera, Deroxat, Cebrilin - mentalhealth.com
Valproate semisodium, divalproex sodium, Depakote, Epival - stanford.edu
Benzodiazepines, including: alprazolam (Xanax), diazepam (Valium), midazolam (Versed), lorazepam (Ativan), oxazepam, and chlordiazepoxide (Librium). [1]

Additional drugs found to be affected by grapefruit juice include

Statins such as atorvastatin, lovastatin, and simvastatin [2]
Dihydropyridines including felodipine (Plendil), nicardipine (Cardene), difedipine, nisoldipine (Sular), nitrendipine (Bayotensin) [3]

losartin (Cozaar) [4]
repaglinide (Prandin) [5]
verapamil (Calan SR, Covera HS, Isoptin SR, Verelan) [6]
Antiarrhythmics including amiodarone (Cordarone), quinidine (Quinidex, Cardioquin, Quinora), disopyramine (Norpace), propafenone (Rhythmol), and carvediol [7]
The male impotence drugs sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) [8] [9]
The anti-migrane drugs ergotamine (Cafergot, Ergomar) and nimodipine (Nimotop) [10]