Larsen syndrome

From Wikipedia, the free encyclopedia

Larsen Syndrome (LS) is a rare autosomal dominant genetic disease that occurs in about every 1 in 100,000 people. Its symptoms include hypermobility, congenital dislocations and distinctive facial features. [1]

The full descriptor of LS is Autosomal Dominant Larsen Syndrome. It is also known as Desbuquois Syndrome.

[edit] Symptoms

A more complete list of symptoms includes:

• Multiple joint dislocations
• Foot deformities
• Non-tapering, cylindrical shaped fingers
• Unusual facial appearance
• Less commonly occurring:
  • Short stature
  • Additional skeletal abnormalities
  • Cleft palate
  • Heart defects
  • Hearing impairment
  • Mental retardation
  • Other miscellaneous abnormalities

[edit] External links

• Cedars-Sinai Entry
• WebMD Abstract
• Online Mendelian Inheritance of Man Entry