Large-conductance mechanosensitive channel
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Mechanosensitive ion channels (MscL) play a critical role in transducing physical stresses at the cell membrane into an electrochemical response [1].
MscL forms a channel organized as a homopentamer, with each subunit containing two transmembrane α-helices. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) that opens in response to stretch forces in the lipid bilayer and participate in the regulation of osmotic pressure within the cell [2].
