Talk:Lamotrigine
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Hi. Iam am just getting on Lamotrigine (25 mg/day for five days--tomorrow I will take 50 mg /day) and find that I am very agitated and more depressed. Is this normal?Gouletan 00:20, 3 December 2006 (UTC)
I can personally attest to the anti-depressant effects. I am taking about 200 mg/day and I have never felt better (39 year old caucasian male). --David Battle 05:49, 23 Nov 2004 (UTC)
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[edit] Rashes and Children
I would suggest that the rash may not limit the prescription of Lamotrigine for children, only require more careful dosing. My 4 year old was prescribed Lamictal for complex partial seizures once the first prescribed medication, Trileptal, stopped working. Thus, I'd think that there's not a real reluctance to prescribe for children. Or the neurologist is a maniac. :) --1Winston 20:23, 1 September 2005 (UTC)
- No, I don't think the neurologist is a maniac, GlaxoSmithKline did extensive trials on pediatric patients. However, since they are at higher risk for SJS, the Prescribing Information indicates that titration and monitoring of possible SJS symptoms require extra care. Lamictal is only indicated though for partial seizures and generalized seizures from Lennox-Gastaut syndrome in children age 2 to 16. --Frankieist 22:07, 1 October 2005 (UTC)
[edit] effective dose
"Side effects Common side effects include headaches, dizziness and insomnia. In very rare cases, Lamotrigine has been known to cause the development of a dangerous rash in some people called Stevens-Johnson syndrome. The rash is more common in children, so this medication is often reserved for adults. There is also an increased incidence of this rash in patients who are currently on, or recently discontinued a valproates anti-convulsant drug, as these medications interact in such a way that the clearance of both is decreased and the effective dose of lamotrigine is increased."
Shouldn't this read that the "effective dose of lamotrigine is decreased" since less would have to be taken for a given level of effectiveness? Or the above passage could be changed to "the effectiveness of a given dose of lamotrigine is increased."
[edit] Attaches to irises?
How much does it alter your thinking? I'm not THAT depressed or bipolar. Not sure if I want to take this anymore... i'm a bit paranoid now.
[edit] Citation needed for acute-symptom usage
The summary currently states that Lamotrigine "is the only anticonvulsant mood stabilizer that treats the depressive as well as the manic phases of bipolar disorders." However, the only clinical studies I've found show inconclusive effects for treatment of acute symptoms, with no statistically significant difference from placebo overall. Likewise, the page notes below that this usage is "off-label." The summary should either provide a citation supporting the claim, or clarify that such usage is not yet well-established.
- I could find no published verification of that claim, so I removed it from the lead paragraph. In its place, I inserted a published assessment. —Aetheling 14:36, 22 November 2006 (UTC)
One could also mention the huge expense of this drug.
