Ku (protein)

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Ku is a heterodimer of two polypeptides, Ku70 and Ku80, so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. Ku binds to DNA double-strand breaks is required for the non-homologous end joining pathway of DNA repair. In many organisms, Ku has been shown to play a role in telomere function.[1]

[edit] References

  1. ^ Boulton SJ, Jackson SP. 1998. Components of the Ku-dependent non-homologous endjoining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819–28 PMID 9501103
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