Ketanserin
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| Ketanserin | |
|---|---|
| Chemical name | - |
| Chemical formula | C22H22FN3O3 |
| Molecular mass | 395.43 g/mol |
| CAS number | 74050-98-9 |
| SMILES | O=C(C4=CC=C(F)C=C4)C(CC3)CCN3 CCN(C2=O)C(NC1=C2C=CC=C1)=O |
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Ketanserin is a serotonin receptor antagonist. It has the highest affinity for the serotonin 5-HT2A receptor, but also binds less potently to the 5-HT2C, 5-HT2B, 5-HT1D, alpha-adrenergic, and dopamine receptors. With tritium radioactively labeled ketanserin is used as a radioligand for the serotonin 5-HT2A receptor, e.g. in receptor binding assays. Ketanserin was discovered at Janssen Pharmaceutica in 1980.
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| Antihypertensives (C02) and diuretics (C03) edit | ||
|---|---|---|
| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: |
Bosentan, Ketanserin |
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| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
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