Kaplan-Meier estimator

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The Kaplan-Meier estimator (also known as the Product Limit Estimator) provides an estimate of the survival function from life-time data. In medical research, it might be used to measure the fraction of patients living for a certain amount of time after surgery. An economist might measure the length of time people remain unemployed after a job loss. An engineer might measure the time until failure of machine parts.

A plot of the Kaplan-Meier estimate of the survival function is a series of horizontal steps of declining magnitude which, when a large enough sample is taken, approaches the true survival function for that population. The value of the survival function between successive distinct sampled observations is assumed to be constant.

An example of a Kaplan-Meier plot for two conditions associated with patient survival
An example of a Kaplan-Meier plot for two conditions associated with patient survival

An important advantage of the Kaplan-Meier curve is that the method can take into account "censored" data — losses from the sample before the final outcome is observed (for instance, if a patient withdraws from a study). On the plot, small vertical tick-marks indicate losses, where patient data has been censored. When no truncation or censoring occurs, the Kaplan-Meier curve is equivalent to the empirical distribution.

In medical statistics, a typical application might involve grouping patients into categories, for instance, those with Gene A profile and those with Gene B profile. In the graph, patients with Gene B die much more quickly than those with gene A. After two years about 80% of the Gene A patients still survive, but less than half of patients with Gene B.

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[edit] Formulation

Let S(t) be the probability that an item from a given population will have a lifetime exceeding t. For a sample from this population of size N let the observed times until death of N sample members be

t_1 \le t_2 \le t_3 \le \cdots \le t_N.

Corresponding to each ti is ni, the number "at risk" just prior to time ti, and di, the number of deaths at time ti.

Note that the intervals between each time typically will not be uniform. For example, a small data set might begin with 10 cases, have a death at day 3, a loss (censored case) at day 9, and another death at day 11. Then we have (t1 = 3,t2 = 11), (n1 = 10,n2 = 8), and (d1 = 1,d2 = 1).

The nonparametric maximum likelihood estimate of S(t) is then a product of the form

\hat S(t) = \prod\limits_{t_i<t} {\frac{{n_i-d_i}}{{n_i}}}

When there is no censoring, ni is just the number of survivors just prior to time ti. With censoring, ni is the number of survivors less the number of losses (censored cases). It is only those surviving cases that are still being observed (have not yet been censored) that are "at risk" of an (observed) death.

[edit] Statistical Considerations

The Kaplan-Meier estimator is a statistic, and several estimators are used to approximate its variance. One of the most common such estimators is Greenwood's Formula, which is as follows

\hat Var( \hat S(t) ) = \hat S(t)^2 * \sum\limits_{t_i<t} {\frac{{d_i}}{{n_i}({n_i-d_i})}}

In some cases, one may wish to compare different Kaplan-Meier curves. This may be done by several method's including:

[edit] References

Kaplan, E.L.; Meier, Paul. "Nonparametric estimation from incomplete observations." J. Am. Stat. Assoc. 53, 457-481 (1958)

Kaplan, E.L in a retrospective on the seminal paper in "This week's citation classic". Current Contents 24, 14 (1983). Available from UPenn as PDF.

Greenwood M. The natural duration of cancer. Reports on Public Health and Medical Subjects. London: Her Majesty's Stationery Office 1926;33:1-26.

[edit] Tools, examples, and tutorials

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