Iron overload disorder
From Wikipedia, the free encyclopedia
| ICD-10 | R79.0 |
|---|---|
| ICD-9 | 790.6 |
In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body.
Contents |
[edit] Causes
[edit] Primary iron overload (see the Haemochromatosis page)
- Type 1: Haemochromatosis associated to mutations in the HFE gene: (Mendelian Inheritance in Man (OMIM) 235200)
- C282Y homozygosity
- C282Y/H63D compound heterozygosity
- Type 2: Juvenile hereditary iron overload (Mendelian Inheritance in Man (OMIM) 602390)
- 2A: mutation of an unknown gene, tentatively called HFE2A
- 2B: mutation in hepcidin antimicrobial peptide (HAMP)
- Type 3: Hereditary iron overload associated to mutations in the transferrin receptor 2 gene (Mendelian Inheritance in Man (OMIM) 604250)
- Type 4: Hereditary iron overload associated to mutations in the SLC11A3 gene (Ferroportin/MTP/IREG-1) (Mendelian Inheritance in Man (OMIM) 606069)
- Aceruloplasminaemia (rare disease) (Mendelian Inheritance in Man (OMIM) 604290)
- Congenital atransferrinaemia (rare disease) (Mendelian Inheritance in Man (OMIM) 209300)
- Others (unidentified genes)
- Juvenile haemochromatosis (Mendelian Inheritance in Man (OMIM) 602390)
- Neonatal haemochromatosis (Mendelian Inheritance in Man (OMIM) 231100)
[edit] Secondary iron overload
- Dietary iron overload
- Transfusional iron overload
- Long term haemodialysis
- Chronic liver disease
- Hepatitis C
- Alcoholic cirrhosis, especially when advanced
- Non-alcoholic steatohepatitis
- Porphyria cutanea tarda
- Post-portacaval shunting
- Dysmetabolic iron overload syndrome
[edit] Miscellaneous
- The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Mendelian Inheritance in Man (OMIM) 601195)
