Interleukin 21

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Interleukin 21
Identifiers
Symbol(s) IL21 ,
Entrez 59067
OMIM 605384
RefSeq NM_021803
UniProt Q9HBE4
Other data
Locus Chr. 4 q26-q27


Interleukin 21 (IL-21), is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. [1][2] This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, that is expressed in bone marrow cells and various lymphocytes.

[edit] References

  1. ^ Parrish-Novak J., S. R. Dillon, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature, 2000, Volume 408, pages 57-63.
  2. ^ Parrish-Novak J, Foster DC, Holly RD, Clegg CH. Interleukin 21 and IL21 Receptor: Novel effectors of NK and T cell responses. Journal of Leukocyte Biology, 2002, Volume 72, pages 856-863.



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Interleukins edit

IL-1 | IL-2 | IL-3 | IL-4 | IL-5 | IL-6 | IL-7 | IL-8 | IL-9 | IL-10 | IL-11 | IL-12 | IL-13 | IL-14 | IL-15 | IL-16 | IL-17 | IL-18 | IL-19 | IL-20 | IL-21 | IL-22 | IL-23 | IL-24 | IL-25 | IL-26 | IL-27 | IL-28 | IL-29 | IL-30 | IL-31 | IL-32 | IL-33 |
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