Interleukin 18

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Solution structure of human IL-18
Interleukin 18
Identifiers
Symbol(s) IL18 , IGIF, IL1F4, IL-1g
Entrez 3606
OMIM 600953
RefSeq NM_001562
UniProt Q14116
PDB 1J0S
Other data
Locus Chr. 11 q22.2-q22.3


Interleukin-18 (IL-18) is a cytokine produced by macrophages that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

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Interleukins edit

IL-1 | IL-2 | IL-3 | IL-4 | IL-5 | IL-6 | IL-7 | IL-8 | IL-9 | IL-10 | IL-11 | IL-12 | IL-13 | IL-14 | IL-15 | IL-16 | IL-17 | IL-18 | IL-19 | IL-20 | IL-21 | IL-22 | IL-23 | IL-24 | IL-25 | IL-26 | IL-27 | IL-28 | IL-29 | IL-30 | IL-31 | IL-32 | IL-33 |
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