Impalefection
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Impalefection is a method of gene delivery using nanomaterials, such as carbon nanofibers, nanotubes, nanowires Ref.1. Needle-like nanostructures are synthesized perpendicular to the surface of a substrate. Plasmid DNA containing the gene, intended for itracellular delivery, is attached to the nanostructure surface. A chip with the arrays of these needles is then pressed against surface bound cell culture. Cells that are impaled by nanostuctures express the delivered gene.
[edit] Etymology
Similar to transfection, the term is derived from two words - impalement and infection.
[edit] References
1. Tracking gene expression after DNA delivery using spatially indexed nanofiber arrays McKnight, T.E., A.V. Melechko, D.K. Hensley, D.G.J. Mann, G.D. Griffin, and M.L. Simpson, . Nano Letters, 2004. 4(7): p. 1213-1219
[edit] External links
- "An Attempted Nanowire Impalefection of Nerve Cells"
- "Intracellular integration of synthetic nanostructures with viable cells for controlled biochemical manipulation"
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