Hypertrophic osteodystrophy

From Wikipedia, the free encyclopedia

You have new messages (last change).

Hypertrophic osteodystrophy is a bone disease in rapidly growing large breed dogs. It may occur between the ages of 2 and 7 months.[1] Symptoms include swelling of the metaphysis (the part of the bone adjacent to the joint), pain, depression, loss of appetite, and fever. The disease is usually bilateral in the limb bones, especially the distal radius, ulna, and tibia. Causes have been speculated to include decreased Vitamin C uptake, increased vitamin (other than C) and mineral uptake, and infection with canine distemper.[1] There is no evidence over-feeding is a significant cause.[2] Some breeds seem to be affected more than others and excess inflammation may be a factor in these breeds in which aggressive treatment is advocated. Some dogs recover within a few days, but some relapse. X-rays show a dark line at the metaphysis, which can progress to new bone growth on the outside of that area. Treatment includes pain medication. Supplementation of Vitamin C is contraindicated due to an increase in calcium levels in the blood, possibly worsening the disease.[3]

[edit] References

  1. ^ a b Thrall, Donald E. (1994). Textbook of Veterinary Diagnostic Radiology, 2nd ed., W.B. Saunders Company. ISBN 0-7216-3143-6.
  2. ^ Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine, 4th ed., W.B. Saunders Company. ISBN 0-7216-6795-3.
  3. ^ Bennett, David;Clements, Dylan J. (2004). "Letters to the Editor". Journal of the American Veterinary Medical Association 225 (1): 29. Retrieved on 2006-05-11.
Retrieved from "http://en.wikipedia.org../../../h/y/p/Hypertrophic_osteodystrophy.html"