HU-210

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HU-210 (CAS# 112830-95-2) is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 percent more potent than natural THC from cannabis and has an extended duration of action. HU-210 is the (+)-1,1-dimethylheptyl analog of 7-hydroxy-delta-6-tetrahydrocannabinol. The abbreviation HU stands for Hebrew University.

Per a 2005 article in the Journal Of Clinical Investigation, HU-210 actually stimulates cell growth in the brain's hippocampus region, an opposite effect of drugs like alcohol, nicotine, heroin, and cocaine.

HU-210, along side WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This antiinflmatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.

[edit] External links

• Wen Jiang and others, "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects", The Journal of Clinical Investigation, 2005. Scientific article about nerve cell growth.
  • Geoff Brumfiel, "Marijuana may make your brain grow. Cannabinoid injections sprout new neurons in mice", Nature, 2005 October (News). Comment in Nature on the article.
• JNeurosci.org Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation