Hot 100 number-one hits of 2003 (USA)
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This is a list of the U.S. Billboard magazine Hot 100 number-ones of 2003.
| Issue Date | Song | Artist |
| January 4 | Lose Yourself | Eminem |
| January 11 | Lose Yourself | Eminem |
| January 18 | Lose Yourself | Eminem |
| January 25 | Lose Yourself | Eminem |
| February 1 | Bump, Bump, Bump | B2K featuring P. Diddy |
| February 8 | All I Have | Jennifer Lopez featuring LL Cool J |
| February 15 | All I Have | Jennifer Lopez featuring LL Cool J |
| February 22 | All I Have | Jennifer Lopez featuring LL Cool J |
| March 1 | All I Have | Jennifer Lopez featuring LL Cool J |
| March 8 | In Da Club | 50 Cent |
| March 15 | In Da Club | 50 Cent |
| March 22 | In Da Club | 50 Cent |
| March 29 | In Da Club | 50 Cent |
| April 5 | In Da Club | 50 Cent |
| April 12 | In Da Club | 50 Cent |
| April 19 | In Da Club | 50 Cent |
| April 26 | In Da Club | 50 Cent |
| May 3 | In Da Club | 50 Cent |
| May 10 | Get Busy | Sean Paul |
| May 17 | Get Busy | Sean Paul |
| May 24 | Get Busy | Sean Paul |
| May 31 | 21 Questions | 50 Cent featuring Nate Dogg |
| June 7 | 21 Questions | 50 Cent featuring Nate Dogg |
| June 14 | 21 Questions | 50 Cent featuring Nate Dogg |
| June 21 | 21 Questions | 50 Cent featuring Nate Dogg |
| June 28 | This Is the Night | Clay Aiken |
| July 5 | This Is the Night | Clay Aiken |
| July 12 | Crazy in Love | Beyoncé featuring Jay-Z |
| July 19 | Crazy in Love | Beyoncé featuring Jay-Z |
| July 26 | Crazy in Love | Beyoncé featuring Jay-Z |
| August 2 | Crazy in Love | Beyoncé featuring Jay-Z |
| August 9 | Crazy in Love | Beyoncé featuring Jay-Z |
| August 16 | Crazy in Love | Beyoncé featuring Jay-Z |
| August 23 | Crazy in Love | Beyoncé featuring Jay-Z |
| August 30 | Crazy in Love | Beyoncé featuring Jay-Z |
| September 6 | Shake Ya Tailfeather | Nelly, P. Diddy and Murphy Lee |
| September 13 | Shake Ya Tailfeather | Nelly, P. Diddy and Murphy Lee |
| September 20 | Shake Ya Tailfeather | Nelly, P. Diddy and Murphy Lee |
| September 27 | Shake Ya Tailfeather | Nelly, P. Diddy and Murphy Lee |
| October 4 | Baby Boy | Beyoncé featuring Sean Paul |
| October 11 | Baby Boy | Beyoncé featuring Sean Paul |
| October 18 | Baby Boy | Beyoncé featuring Sean Paul |
| October 25 | Baby Boy | Beyoncé featuring Sean Paul |
| November 1 | Baby Boy | Beyoncé featuring Sean Paul |
| November 8 | Baby Boy | Beyoncé featuring Sean Paul |
| November 15 | Baby Boy | Beyoncé featuring Sean Paul |
| November 22 | Baby Boy | Beyoncé featuring Sean Paul |
| November 29 | Baby Boy | Beyoncé featuring Sean Paul |
| December 6 | Stand Up | Ludacris featuring Shawnna |
| December 13 | Hey Ya! | OutKast |
| December 20 | Hey Ya! | OutKast |
| December 27 | Hey Ya! | OutKast |
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